MiyamaWellness – Cancer COPD Fibrosis Hydrogen Therapy

Cancer, COPD, Addiction, Autoimmune.

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Molecular Hydrogen is a potent antioxidant agent and cell signal modulator which effectively targets mitochondria to reduce inflammation and activate or enhance endogenous antioxidant defense system.

Immune system imbalance is caused by oxidative stress and chronic inflammation. Antioxidant/ anti-inflammatory therapies capable of restoring immune system balance are best choices for treating chronic noncommunicable diseases.

A highly active immune system may induce autoimmune diseases. A weakened immune system encourages cancer initiation.

Innovative Hydrogen Therapy for Fighting Chronic Diseases

Fibrosis

Fibrosis, a hallmark of numerous chronic inflammatory conditions, represents a formidable challenge in modern healthcare due to its pervasive impact on organ function and mortality rates. The pathological process of fibrosis, characterized by the excessive accumulation of extracellular matrix components, is intricately intertwined with chronic inflammation and metabolic imbalances. Formerly perceived as an irreversible cascade, recent scientific endeavors have unveiled the dynamic nature of fibrosis, offering new avenues for therapeutic intervention.

Myofibroblasts, arising from diverse cellular sources, emerge as central players in organ fibrosis, embryonic development, and the stromal response to malignancies. Moreover, the interplay between oxidative stress, inflammation, and immunity shapes the fibrotic milieu, highlighting the multifaceted nature of this pathological process. This evolving comprehension of fibrosis not only enhances the grasp of disease mechanisms but also fosters optimism for innovative treatment modalities aimed at mitigating its devastating consequences.

Recent estimates suggest that fibrotic disease is responsible for almost half of all deaths in Western developed countries.

Fibrosis affects nearly all tissues and organ systems.

Fibrosis is a dynamic process with the potential for reversibility and restoration of near-normal tissue architecture and organ function.

Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli including autoimmune diseases, persistent infections, allergic responses, chemotherapy drugs (and some other drugs), radiation, chemical insults and tissue injury (physical or ischemic).

Fibrosis is a pathological feature of most chronic inflammatory autoimmune diseases.

The underlying molecular and cellular events of fibrotic autoimmune diseases share many functional similarities, despite differences in aetiology and clinical evolution.

Most of the current therapeutic agents target the terminal phase of the chronic inflammation of autoimmune diseases and do not address the fundamental problems that are responsible for the initiation and progression of the autoimmune process which often leads to organ fibrosis.

Lately, accumulating studies from human and animal models suggest that the potential to reverse fibrotic changes exists in most organs/ tissues studied, including the liver, lung, kidney, skeletal muscle, heart, and bone marrow.

The time required for the resolution of fibrosis may vary depending on the organ involved, the cause of injury, and host-specific factors such as age, genetic and epigenetic background, immune competence and antioxidants applied.

Hydrogen therapy emerged as a promising antioxidant therapy for treating immune-mediated/ autoimmune diseases. In many inflammatory diseases, inflammation is mainly caused by the over-activation of pro-inflammatory substances of the immune system.

HYDROGEN THERAPY: An Antioxidant/ Cell Signal Modulating Approach for Chronic Disease Treatment

Fibrosis, as end result of many chronic illnesses like COPD, Cirrhosis, Chronic Kidney Disease and Cancer, stems from oxidative stress and chronic inflammation.

The following are the most straightforward ways to reduce oxidative stress and chronic inflammation:

1) Applying exogenous antioxidants to scavenge excessive and harmful ROS (reactive oxygen species).

This is apparently a convenient therapeutic approach. However, all organic compounds react with •OH with similar rate constants approaching diffusion limitation. Thus, no exogenous antioxidant compound has more •OH scavenging activity than the millions of protein molecules already present even in a simple cell. Therefore the actual effect of scavenging by exogenous antioxidant compound is negligible.

2) Applying a cell signal modulator to activate or enhance endogenous antioxidant defense systems.

To defend against oxidative injury, organisms have evolved defenses primarily dependent upon antioxidant enzymes, supply of their substrates and repair of injury. In response to oxidants and other electrophiles, these defenses increase and thereby boost the capacity to detoxify oxidants and/or electrophiles and repair oxidative damage. Agents that enhance these defenses are the principal strategies underlying antioxidant therapy.

Advantages of Hydrogen Therapy

While traditional antioxidant therapies have largely faltered in clinical trials, the emergence of hydrogen therapy offers renewed hope. Unlike traditional antioxidant supplements or diets, hydrogen therapy exhibits unique properties that make it a potent antioxidant agent and cell signal modulator, effectively targeting mitochondria which produce excessive and harmful ROS.

Compared with traditional exogenous antioxidants, molecular hydrogen (H2) has many advantages some of which are listed below:

H2 can diffuse readily through the BBB (Blood Brain Barrier), IB (Intestinal Barrier), cell membranes and mitochondria.

H2 has high antioxidant and anti-inflammatory capacities.

H2 is totally natural. The gut microbiota of a healthy person may produce 100 to 1,000 ml of hydrogen gas in 24 hours. There are more than 100 trillion intestinal bacteria from 1,000 different species in the large intestine. Among these, 70% are hydrogen-producing bacteria.

H2 application is carried out only by noninvasive methods.

H2 can be administered locally to raise hydrogen concentration levels in a small area.

With its ability to mitigate oxidative stress and chronic inflammation, hydrogen therapy presents a promising avenue for managing a broad spectrum of chronic diseases.

Hydrogen’s immunomodulatory function on the immune system:

When inflammation occurs, the malfunctioned immune cells break the immune homeostasis.

Hydrogen intervention could reduce inflammation by down-regulating pro-inflammatory cells and/or up-regulating anti-inflammatory cells, to recover the immune homeostasis.

REF: Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis

Cancer is an Immune-mediated Disease.

Tumors are like wounds that do not heal.

The immune system is closely intertwined with both cancer pathogenesis and treatment. Cancer is a manifestation of malfunctions in immunity, as malignant cells manage to escape recognition and elimination by the immune system.

Chronic infections and inflammation associated with limited immune responses also contribute to carcinogenesis and tumor progression.

Ref: Cancer as an immune-mediated disease

The characteristics of solid tumor microenvironment (TME) mainly fall into these categories:

1) Chronic Inflammation,

2) Tumor Fibrosis,

3) Low Extracellular pH,

4) Immunosuppression,

5) Hypoxia (low oxygen) and

6) High Interstitial Fluid Pressure.

They complement each other and form a complex mechanistic network, which plays a key role in many steps during tumor development, such as local drug resistance, immune escape, and distant metastasis.

Therapies

Numerous pro-oxidant strategies are developed, some of which have become mainstream anti-cancer treatments in clinical practice, such as radiotherapy and chemotherapy. However, these strategies also have many destructive effects on normal tissues and organs, which are even life-threatening. Upon further studies of the mechanisms of their adverse effects, these drugs are frequently found to be hemotoxic because they cause sharp ROS accumulation and/or disrupt the endogenous antioxidant defense systems

In recent years, a series of studies have confirmed that hydrogen, a weakly reductive gas, also has therapeutic effects on various cancers and can mitigate oxidative stress caused by radiation and chemotherapy, reducing tissue damage and immunosuppression to improve prognosis. Hydrogen therapy emerged as a nontoxic antioxidant strategy which does not interfere with normal cellular functions.

Ref: Role of TME in cancer progression and therapeutic strategy

Prospects of hydrogen in cancer prevention and treatment

Hydrogen Gas in Cancer Treatment

Hydrogen Therapy – A Review on Clinical Studies and Outcomes

Drug-induced oxidative stress in cancer treatments

Association between pH regulation of the TME and immunological state

Mitochondria Dysfunction, Diseases

Mitochondria consume approximately 90% of the body’s oxygen to generate ATP through oxidative phosphorylation, rendering them a significant source of ROS (Reactive Oxygen species).

Cells employ a multifaceted antioxidant defense system to regulate ROS levels and prevent oxidative stress.

ROS also act as vital signaling molecules engaged in regulating numerous biological processes.

Molecular Hydrogen is a nontoxic, mitochondria-targeting antioxidant which also acts as a cell signaling modulator, capable of activating or enhancing endogenous antioxidant system.

Molecular hydrogen does not interfere with normal cellular functions.

Ref: ROS Signaling and Oxidative Stress

Mitochondria in Health and Disease

Hydrogen: A Rising Star in Gas Medicine as a Mitochondria-Targeting Nutrient via Activating Keap1-Nrf2 Antioxidant System

Self-care Can Improve Physical and Emotional Health

Empowering Self-care with Hydrogen Therapy

Hydrogen therapy can be implemented as a complementary therapy or stand-alone therapy in patients´ homes for Self-care Wellness Programs since the administration of hydrogen is simple, noninvasive and nontoxic.

Hydrogen inhalers use pure water to produce hydrogen by electrolysis. Normally, these hydrogen inhalers employ PEM (Proton Exchange Membrane) technology to separate hydrogen and oxygen.

An increasing number of studies have revealed that hydrogen may protect the lungs from diverse diseases, including acute lung injury, COPD, asthma, lung cancer, pulmonary arterial hypertension, and pulmonary fibrosis. The main effect of hydrogen on the immune system is to reduce the production of immune active substances. Evidence suggests that molecular hydrogen relieves inflammation in autoimmune diseases.

The preventive and therapeutic effects of hydrogen have been intensively investigated for various pathological processes. There are many recently published studies which cover the use of hydrogen in respiratory, cardiovascular, nervous, digestive, reproductive, urinary, motor, and sensory system diseases, as well as for the treatment of metabolic syndrome and cancer.

Pro-oxidant therapies do not eliminate all cancerous cells, do not address the immunosuppressive nature of the disease and can further impair the patient’s immune response weakening the patient’s resistance to the cancer.

Compared with pro-oxidant therapies and traditional antioxidant therapies (supplements, diet changes and drugs), hydrogen-based therapy is a promising nontoxic and non-pharmacological approach which has shown good potential for alleviating oxidative stress, chronic inflammation and lowering lactate concentration levels in tissues and organs.

Ref: Hydrogen: A Novel Option in Human Disease Treatment

Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases

Association between pH regulation of the tumor microenvironment and immunological state

Cancer as an immune-mediated disease

DISEASES Which May Benefit From Hydrogen Therapy

Hydrogen therapy may offer help to patients with various chronic diseases some of which are listed below:

Autoimmune/ Immune-mediated Diseases:

COPD,

Asthma,

Atopic Dermatitis,

Ankylosing Spondylitis,

Lupus (SLE).

Central Nervous System Diseases:

Addictions (of Alcohol and Opioids),

Stroke Paralysis,

Parkinson’s Disease,

Epilepsy,

Pain (caused by cancer).

Fibrotic Diseases:

Cancer Fibrosis (in solid tumors or in tissues damaged by conventional cancer treatments),

Kidney Fibrosis (Diabetic Renal Deficiency),

Liver Fibrosis (Cirrhosis),

Spleen fibrosis,

Eye fibrosis (Cataracts, Diabetic Retinopathy).

Contact us for more information.

Hydrogen Therapy is considered as a Complementary Wellness Program intended for improving patients’ general wellbeing. Hydrogen Therapy is not a substitute for patients’ current conventional treatments. Actual user responses may be different in each case.

Sales and Delivery of Hydrogen Generating Devices

Miyama Wellness offers/sells most suitable hydrogen generating devices for hydrogen inhalation and hydrogen-rich water drinking. Discounts are available for financially underprivileged patients. Contact us for more information.

Shipment schedule may vary according to where the buyer is located.

The devices and accessories are not medical devices. All devices have a limited warranty for 12 months.

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